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Write USPaxman have been ‘Chasing Zero Hair Loss’ for many years and will continue until we reach a point where all chemotherapy patients worldwide are offered scalp cooling. In parallel we have also worked intensively to increase the number of patients who can keep most of their hair using scalp cooling. The more we know about the molecular mechanisms of scalp cooling, the more we can evolve our development methods to achieve the most efficacious system and cap as possible using clinical research and evidence based information.